Projects

Variant Curation Service

SDE, Strand Life Sciences|Feb 2024 – Present

Next.js

MUI

Node.js

MongoDB

Developed the VIQ Scoring Wizard to automate variant classification using SOP guidelines.
Built a custom JSON rule-based curation engine to assess variant pathogenicity.
Designed dynamic UI components, modular backend APIs, and schema migrations for evolving rules.
Optimized MongoDB indexing to support real-time variant retrieval and penetrance modeling.

SDE, Strand Life Sciences|Aug 2023 – Feb 2024

Next.js

MUI

Node.js

AWS Athena

Created an automated DAF platform to analyze transcript-level variant frequencies.
Integrated gnomAD, ClinVar, and internal databases for large-scale data analysis.
Engineered scalable backend APIs and parsing logic for ClinVar and gnomAD VEP annotations.
Improved performance with variant filtering pipelines for accurate DAF calculations.

SDE, Strand Life Sciences|Jul – Aug 2023

Python

Genomics

BWT

Suffix Trees

Implemented custom DNA read alignment algorithms using Suffix Trees and BWT.
Reduced alignment time per read to under 1 second using optimized data structures.
Analyzed over 3 million reads to identify genetic anomalies related to color blindness.
Simulated theoretical mutation mosaics and supported X-linked inheritance theories.

Intern, Strand Life Sciences|May – Jul 2022

React

Redux

MUI

Flask

NetworkX

Built a search platform to return top 20 articles ranked by phenotype relevance.
Improved similarity scoring logic inspired by PMC6128307 for higher accuracy.
Optimized caching and graph traversal on large biomedical datasets.
Developed a responsive UI with multi-phenotype support and relevance-based ranking.

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